Defective neutrophil rolling and transmigration in acute uremia
نویسندگان
چکیده
منابع مشابه
Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium.
Polymorphonuclear leukocyte (PMN) recruitment to vascular endothelium during acute inflammation involves cooperation between selectins, G-proteins, and beta2-integrins. LFA-1 (CD11a/CD18) affinity correlates with specific adhesion functions because a shift from low to intermediate affinity supports rolling on ICAM-1, whereas high affinity is associated with shear-resistant leukocyte arrest. We ...
متن کاملNeutrophil apoptosis and dysfunction in uremia.
The high prevalence of bacterial infections among patients with end-stage renal disease suggests that "professional" phagocytes such as neutrophils are functionally impaired. This dysfunction has been ascribed to uremic toxins, malnutrition, and dialysis. The aim of this study was to investigate the contribution of apoptosis to neutrophil dysfunction in uremia. Neutrophils harvested from uremic...
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Recruitment of leukocytes circulating in our blood to the sites of infection or tissue damage is the key phenomenon in the acute inflammatory response(s). Among the leukocytes, neutrophils are primarily recruited into the areas of acute inflammation. When neutrophils interact with activated endothelium of the blood vessels, they become migratory and cross the endothelial layer of the blood vess...
متن کاملDynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium Running Title: LFA-1 affinity regulates neutrophil recruitment
1 University of California, Davis. Department of Biomedical Engineering. Genome and Biomedical Sciences Facility, 451 E. Health Sciences Dr., Davis, California, 95616-5294. 530-752-1430 (U. S., A. F. H. L., M. R. S.) 530-754-2193 (C. E. G.), 530-752-0299 (S. I. S.). Fax 530-754-5739 2 ICOS Corporation, 22021 20 Ave. SE, Bothell, Washington 98021. 3 Current Address: The Scripps Research Institut...
متن کاملPathophysiology of acute uremia
Pathophysiology of acute uremia Acute renal failure has traditionally been classified as Pre-renal, intrinsic renal, and/or Post-renal in origin. Careful scrutiny of history, physical examination, laboratory findings and imaging studies of cats presenting with signs of an acute uremic crisis usually provides adequate information to identify Pre-renal, renal and Post-renal components of uremia. ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2011
ISSN: 0085-2538
DOI: 10.1038/ki.2011.169